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By Michael Balls, James Bridges, Jacqueline Southee

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Extra resources for Animals and Alternatives in Toxicology: Present Status and Future Prospects

Sample text

37) found that severe skin irritation correlated with severe eye irritation in most instances, but in 8% of the cases studied, minor skin irritation failed to indicate subsequent severe eye irritant potential. Conversely, Williams (38), in a survey of 60 primary skin irritants, found a relative lack of correspondingly severe eye irritation potential in over a third of the compounds; the situation thus contains uncertainties. Nevertheless, the demonstration of severe primary dermal irritation should preclude the need for subsequent eye testing, unless valid reasons can be shown to the contrary.

6. Anon. (1978). Council Directive 781631/EEC as to the classification, packaging and labelling of dangerous preparations (pesticides). Official Journal of the European Communities L206, 13--23. 7. US Environmental Protection Agency (1978). Proposed guidelines for registering pesticides in the US. Hazard evaluation: humans and domestic animals. Federal Register 43, 3733637345,37351-37356. 8. Anon. (1976). Council Directive 761768/EEC on the approximation of the laws of Member States relating to cosmetic products.

2. Systems for classifying ocular hazard should be harmonised to give a consistent material hazard rating. 3. Stepwise approaches should be considered by regulatory authorities for possible incorporation into guidelines. 4. Further possibilities for labelling materials as eye irritants on the basis of demonstrable primary skin irritancy only, should be explored. 5. Humane considerations permitting, dermal irritancy data from multiple site studies should be accepted in regulatory guidelines, in the interests of reducing animal numbers.

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