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By Maya Tiwari

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After hospitalization, she had many tests, all normal. No cause was found for the seizure. Meanwhile, unawares, she continued using Equal. One day she consumed more than her usual amount and developed the left-temporal headache again. That night at a party she had a drink of rum (probably not a good idea for someone prone to seizures) and while dancing she experienced another major seizure, which was witnessed by several doctors who were present. She continued having two to three headaches a week, and about a month later she had a 1-ounce drink of rum with guests at dinner and again had a seizure.

Normally active dogs, on the other hand, simply get more excited, As we have pointed out, aspartame contains phenylalanine, required by the brain for making dopamine and norepinephrine. It does not seem too farfetched to consider that an unexpected large influx of phenylalanine to the brain somehow disrupts the balance in the dopamine-norepinephrine system, especially in young children whose system is in the process of developing or in hyperactive children who already have a tenuous balance among their neurotransmitters.

The facts do not warrant such a conclusion. The FDA has to make a reasonable judgment that protects the public interest from harm, but it also has to consider the benefits of a new product and not obstruct its availability. Further research has continued to suggest that aspartame is not carcinogenic. But what is striking about this whole episode is the narrow focus on physical risks, with no attention paid to possible behavioral risks. Behavioral toxicology hardly came into the discussion at all.

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